Reduced prefrontal cortex response to own vs. unknown emotional infant faces in mothers with bipolar disorder
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Motherhood involves functional brain adaptations within a broad neural network purported to underlie sensitive caregiving behavior. Bipolar disorder (BD) is associated with aberrant brain response to emotional faces within a similar network, which may influence BD mothers’ sensitivity to infant faces. This functional magnetic resonance imaging (fMRI) study aimed to investigate whether mothers with BD display aberrant neural responses to own infant faces compared to healthy mothers. Twenty-six mothers with BD in remission and 35 healthy mothers underwent fMRI during which they viewed happy and distressed still facial photographs of their own and of unknown infants. After the scan, mothers viewed the pictures again on a computer screen and rated the intensity of infants’ facial emotions and their own emotional response to infant face images. Mothers with BD displayed lower left dorsolateral prefrontal cortex (dlPFC) response compared to healthy mothers to own vs. unknown infant faces specifically and abnormal positive functional connectivity between the left and right amygdala and prefrontal regions. BD mothers further displayed stronger deactivation of precuneus and occipital regions to all happy vs. distressed infant faces. After the scan, they rated their infants’ distress and own response to their infants’ distressed faces less negatively than healthy mothers. Blunted dlPFC response and aberrant fronto-limbic connectivity while viewing own infant faces and less negative ratings of own infants’ distress in BD mothers may affect their responses to their own infants in real-life mother-infant interactions.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Neuropsychopharmacology |
| Vol/bind | 54 |
| Sider (fra-til) | 7-20 |
| Antal sider | 14 |
| ISSN | 0924-977X |
| DOI | |
| Status | Udgivet - jan. 2022 |
Bibliografisk note
Funding Information:
We acknowledge the Research Fund of the Mental Health Services in the Capital Region of Denmark, the Augustinus Foundation, Hartmann Foundation, L'Or?al for Women in Science, Ivan Nielsen Foundation and A.P. M?ller Foundation for funding this project. KWM acknowledges the Lundbeck Foundation for her five-year Lundbeck Foundation Fellowship (grant no. R215-2015-4121). We are grateful to PhD Tue Hvass Petersen, Sr. Customer Success Manager at iMotions A/S for his valuable technical assistance in setting-up computer tasks and processing psychophysiological data. We thank Tina Wahl Haase, MSc. in psychology at The Department of Psychology, University of Copenhagen, for coding CIB reliability. We thank MD Rie Lamb?k Mikkelsen, psychiatrist at Psychiatric Centre Copenhagen, for her help with mediated the contact to participants with mood disorder.
Funding Information:
This work was supported by a grant from the Research Fund of the Mental Health Services in the Capital Region of Denmark, the Augustinus Foundation, Hartmann Foundation, L'Oréal for Women in Science, Ivan Nielsen Foundation and A.P. Møller Foundation. The sponsors had no role in the conception of the study, the study design, the analysis or interpretation of the results or in the dissemination of the findings.
Funding Information:
We acknowledge the Research Fund of the Mental Health Services in the Capital Region of Denmark, the Augustinus Foundation, Hartmann Foundation, L'Oréal for Women in Science, Ivan Nielsen Foundation and A.P. Møller Foundation for funding this project. KWM acknowledges the Lundbeck Foundation for her five-year Lundbeck Foundation Fellowship (grant no. R215-2015-4121). We are grateful to PhD Tue Hvass Petersen, Sr. Customer Success Manager at iMotions A/S for his valuable technical assistance in setting-up computer tasks and processing psychophysiological data. We thank Tina Wahl Haase, MSc. in psychology at The Department of Psychology, University of Copenhagen, for coding CIB reliability. We thank MD Rie Lambæk Mikkelsen, psychiatrist at Psychiatric Centre Copenhagen, for her help with mediated the contact to participants with mood disorder.
Publisher Copyright:
© 2021 The Authors
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