Reduced prefrontal cortex response to own vs. unknown emotional infant faces in mothers with bipolar disorder
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Reduced prefrontal cortex response to own vs. unknown emotional infant faces in mothers with bipolar disorder. / Bjertrup, Anne; Macoveanu, Julian; Laurent, Heidemarie; Moszkowicz, Mala; Finnegan, Megan Kate; Egmose, Ida; Fisher, Patrick Mac Donald; Nielsen, René Ernst; Pagsberg, Anne Katrine; Kessing, Lars Vedel; Væver, Mette; Miskowiak, Kamilla.
I: European Neuropsychopharmacology, Bind 54, 01.2022, s. 7-20.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Reduced prefrontal cortex response to own vs. unknown emotional infant faces in mothers with bipolar disorder
AU - Bjertrup, Anne
AU - Macoveanu, Julian
AU - Laurent, Heidemarie
AU - Moszkowicz, Mala
AU - Finnegan, Megan Kate
AU - Egmose, Ida
AU - Fisher, Patrick Mac Donald
AU - Nielsen, René Ernst
AU - Pagsberg, Anne Katrine
AU - Kessing, Lars Vedel
AU - Væver, Mette
AU - Miskowiak, Kamilla
N1 - Publisher Copyright: © 2021 The Authors
PY - 2022/1
Y1 - 2022/1
N2 - Motherhood involves functional brain adaptations within a broad neural network purported to underlie sensitive caregiving behavior. Bipolar disorder (BD) is associated with aberrant brain response to emotional faces within a similar network, which may influence BD mothers’ sensitivity to infant faces. This functional magnetic resonance imaging (fMRI) study aimed to investigate whether mothers with BD display aberrant neural responses to own infant faces compared to healthy mothers. Twenty-six mothers with BD in remission and 35 healthy mothers underwent fMRI during which they viewed happy and distressed still facial photographs of their own and of unknown infants. After the scan, mothers viewed the pictures again on a computer screen and rated the intensity of infants’ facial emotions and their own emotional response to infant face images. Mothers with BD displayed lower left dorsolateral prefrontal cortex (dlPFC) response compared to healthy mothers to own vs. unknown infant faces specifically and abnormal positive functional connectivity between the left and right amygdala and prefrontal regions. BD mothers further displayed stronger deactivation of precuneus and occipital regions to all happy vs. distressed infant faces. After the scan, they rated their infants’ distress and own response to their infants’ distressed faces less negatively than healthy mothers. Blunted dlPFC response and aberrant fronto-limbic connectivity while viewing own infant faces and less negative ratings of own infants’ distress in BD mothers may affect their responses to their own infants in real-life mother-infant interactions.
AB - Motherhood involves functional brain adaptations within a broad neural network purported to underlie sensitive caregiving behavior. Bipolar disorder (BD) is associated with aberrant brain response to emotional faces within a similar network, which may influence BD mothers’ sensitivity to infant faces. This functional magnetic resonance imaging (fMRI) study aimed to investigate whether mothers with BD display aberrant neural responses to own infant faces compared to healthy mothers. Twenty-six mothers with BD in remission and 35 healthy mothers underwent fMRI during which they viewed happy and distressed still facial photographs of their own and of unknown infants. After the scan, mothers viewed the pictures again on a computer screen and rated the intensity of infants’ facial emotions and their own emotional response to infant face images. Mothers with BD displayed lower left dorsolateral prefrontal cortex (dlPFC) response compared to healthy mothers to own vs. unknown infant faces specifically and abnormal positive functional connectivity between the left and right amygdala and prefrontal regions. BD mothers further displayed stronger deactivation of precuneus and occipital regions to all happy vs. distressed infant faces. After the scan, they rated their infants’ distress and own response to their infants’ distressed faces less negatively than healthy mothers. Blunted dlPFC response and aberrant fronto-limbic connectivity while viewing own infant faces and less negative ratings of own infants’ distress in BD mothers may affect their responses to their own infants in real-life mother-infant interactions.
KW - Bipolar disorder
KW - Cognitive neuroscience
KW - Facial recognition
KW - fMRI
KW - Mother-child relations
U2 - 10.1016/j.euroneuro.2021.09.011
DO - 10.1016/j.euroneuro.2021.09.011
M3 - Journal article
C2 - 34706300
AN - SCOPUS:85117700550
VL - 54
SP - 7
EP - 20
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
SN - 0924-977X
ER -
ID: 288919688