Short-Term versus Long-Term Mentalization-Based Therapy for Borderline Personality Disorder: A Randomized Clinical Trial (MBT-RCT)
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Short-Term versus Long-Term Mentalization-Based Therapy for Borderline Personality Disorder : A Randomized Clinical Trial (MBT-RCT). / Juul, Sophie; Jakobsen, Janus Christian; Hestbaek, Emilie; Jørgensen, Caroline Kamp; Olsen, Markus Harboe; Rishede, Marie; Frandsen, Frederik Weischer; Bo, Sune; Lunn, Susanne; Poulsen, Stig; Sørensen, Per; Bateman, Anthony; Simonsen, Sebastian.
I: Psychotherapy and Psychosomatics, Bind 92, Nr. 5, 2023, s. 329-339.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Short-Term versus Long-Term Mentalization-Based Therapy for Borderline Personality Disorder
T2 - A Randomized Clinical Trial (MBT-RCT)
AU - Juul, Sophie
AU - Jakobsen, Janus Christian
AU - Hestbaek, Emilie
AU - Jørgensen, Caroline Kamp
AU - Olsen, Markus Harboe
AU - Rishede, Marie
AU - Frandsen, Frederik Weischer
AU - Bo, Sune
AU - Lunn, Susanne
AU - Poulsen, Stig
AU - Sørensen, Per
AU - Bateman, Anthony
AU - Simonsen, Sebastian
N1 - Publisher Copyright: © 2023 The Author(s). Published by S. Karger AG, Basel.
PY - 2023
Y1 - 2023
N2 - Introduction: Borderline personality disorder (BPD) is a severe and prevalent psychiatric disorder. Mentalization-based therapy (MBT) is an evidence-based intervention for BPD, and several countries offer treatment programs for BPD lasting for years, which is resource demanding. No previous trial has compared short-term with long-term MBT. Objective: The aim of the study was to assess the efficacy and safety of short-term versus long-term MBT for outpatients with BPD. Methods: Adult outpatients (≥18 years) with subthreshold or diagnosed BPD were randomly assigned (1:1) to short-term MBT (5 months) or long-term MBT (14 months). The primary outcome was BPD symptoms assessed with the Zanarini Rating Scale for Borderline Personality Disorder. Secondary outcomes were functional impairment, quality of life, global functioning, and severe self-harm. All outcomes were primarily assessed at 16 months after randomization. Results: Between October 4, 2018, and December 3, 2020, we randomly assigned 166 participants to short-term MBT (n = 84) or long-term MBT (n = 82). Regression analyses showed no evidence of a difference when assessing BPD symptoms (MD 0.99; 95% CI: -1.06 to 3.03; p = 0.341), level of functioning (MD 1.44; 95% CI: -1.43 to 4.32; p = 0.321), quality of life (MD -0.91; 95% CI: -4.62 to 2.79; p = 0.626), global functioning (MD -2.25; 95% CI: -6.70 to 2.20; p = 0.318), or severe self-harm (RR 1.37; 95% CI: 0.70-2.84; p = 0.335). More participants in the long-term MBT group had a serious adverse event compared with short-term MBT (RR 1.63; 95% CI: 0.94-3.07; p = 0.088), primarily driven by a difference in psychiatric hospitalizations (RR 2.03; 95% CI: 0.99-5.09; p = 0.056). Conclusion: Long-term MBT did not lead to lower levels of BPD symptoms, nor did it influence any of the secondary outcomes compared with short-term MBT.
AB - Introduction: Borderline personality disorder (BPD) is a severe and prevalent psychiatric disorder. Mentalization-based therapy (MBT) is an evidence-based intervention for BPD, and several countries offer treatment programs for BPD lasting for years, which is resource demanding. No previous trial has compared short-term with long-term MBT. Objective: The aim of the study was to assess the efficacy and safety of short-term versus long-term MBT for outpatients with BPD. Methods: Adult outpatients (≥18 years) with subthreshold or diagnosed BPD were randomly assigned (1:1) to short-term MBT (5 months) or long-term MBT (14 months). The primary outcome was BPD symptoms assessed with the Zanarini Rating Scale for Borderline Personality Disorder. Secondary outcomes were functional impairment, quality of life, global functioning, and severe self-harm. All outcomes were primarily assessed at 16 months after randomization. Results: Between October 4, 2018, and December 3, 2020, we randomly assigned 166 participants to short-term MBT (n = 84) or long-term MBT (n = 82). Regression analyses showed no evidence of a difference when assessing BPD symptoms (MD 0.99; 95% CI: -1.06 to 3.03; p = 0.341), level of functioning (MD 1.44; 95% CI: -1.43 to 4.32; p = 0.321), quality of life (MD -0.91; 95% CI: -4.62 to 2.79; p = 0.626), global functioning (MD -2.25; 95% CI: -6.70 to 2.20; p = 0.318), or severe self-harm (RR 1.37; 95% CI: 0.70-2.84; p = 0.335). More participants in the long-term MBT group had a serious adverse event compared with short-term MBT (RR 1.63; 95% CI: 0.94-3.07; p = 0.088), primarily driven by a difference in psychiatric hospitalizations (RR 2.03; 95% CI: 0.99-5.09; p = 0.056). Conclusion: Long-term MBT did not lead to lower levels of BPD symptoms, nor did it influence any of the secondary outcomes compared with short-term MBT.
KW - Borderline personality disorder
KW - Mentalization-based therapy
KW - Randomized clinical trial
KW - Short-term psychotherapy
U2 - 10.1159/000534289
DO - 10.1159/000534289
M3 - Journal article
C2 - 37935133
AN - SCOPUS:85177597084
VL - 92
SP - 329
EP - 339
JO - Psychotherapy and Psychosomatics
JF - Psychotherapy and Psychosomatics
SN - 0033-3190
IS - 5
ER -
ID: 381780444