Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction. / Koehler-Forsberg, Kristin; Dam, Vibeke H.; Ozenne, Brice; Sankar, Anjali; Beliveau, Vincent; Landman, Elizabeth B.; Larsen, Søren V.; Poulsen, Asbjørn S.; Ip, Cheng-Teng; Jørgensen, Anders; Meyer, Michal; Stenbaek, Dea S.; Eiberg, Hans R. L.; Madsen, Jacob; Svarer, Claus; Jorgensen, Martin B.; Frokjaer, Vibe G.; Knudsen, Gitte M.

I: JAMA Psychiatry, Bind 80, Nr. 4, 2023, s. 296-304.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Koehler-Forsberg, K, Dam, VH, Ozenne, B, Sankar, A, Beliveau, V, Landman, EB, Larsen, SV, Poulsen, AS, Ip, C-T, Jørgensen, A, Meyer, M, Stenbaek, DS, Eiberg, HRL, Madsen, J, Svarer, C, Jorgensen, MB, Frokjaer, VG & Knudsen, GM 2023, 'Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction', JAMA Psychiatry, bind 80, nr. 4, s. 296-304. https://doi.org/10.1001/jamapsychiatry.2022.4539

APA

Koehler-Forsberg, K., Dam, V. H., Ozenne, B., Sankar, A., Beliveau, V., Landman, E. B., Larsen, S. V., Poulsen, A. S., Ip, C-T., Jørgensen, A., Meyer, M., Stenbaek, D. S., Eiberg, H. R. L., Madsen, J., Svarer, C., Jorgensen, M. B., Frokjaer, V. G., & Knudsen, G. M. (2023). Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction. JAMA Psychiatry, 80(4), 296-304. https://doi.org/10.1001/jamapsychiatry.2022.4539

Vancouver

Koehler-Forsberg K, Dam VH, Ozenne B, Sankar A, Beliveau V, Landman EB o.a. Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction. JAMA Psychiatry. 2023;80(4):296-304. https://doi.org/10.1001/jamapsychiatry.2022.4539

Author

Koehler-Forsberg, Kristin ; Dam, Vibeke H. ; Ozenne, Brice ; Sankar, Anjali ; Beliveau, Vincent ; Landman, Elizabeth B. ; Larsen, Søren V. ; Poulsen, Asbjørn S. ; Ip, Cheng-Teng ; Jørgensen, Anders ; Meyer, Michal ; Stenbaek, Dea S. ; Eiberg, Hans R. L. ; Madsen, Jacob ; Svarer, Claus ; Jorgensen, Martin B. ; Frokjaer, Vibe G. ; Knudsen, Gitte M. / Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction. I: JAMA Psychiatry. 2023 ; Bind 80, Nr. 4. s. 296-304.

Bibtex

@article{fcc4f9a0722344ce8882fa718b40c9a5,
title = "Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction",
abstract = "IMPORTANCE The cerebral serotonin 4 (5-HT4) receptor is a promising novel target for treatment of major depressive disorder (MDD), and pharmacological stimulation of the 5-HT4 receptor has been associated with improved learning and memory in healthy individuals.OBJECTIVE To map the neurobiological signatures of patients with untreated MDD compared with healthy controls and to examine the association between cerebral 5-HT4 receptor binding and cognitive functions in the depressed state.DESIGN, SETTING, AND PARTICIPANTS This case-control study used baseline data from the NeuroPharm clinical depression trial in Denmark. Adult participants included antidepressant-free outpatients with a current moderate to severe depressive episode and healthy controls. All participants completed positron emission tomography (PET) scanning with [C-11]SB207145 for quantification of brain 5-HT4 receptor binding, but only the patients underwent cognitive testing. Data analyses were performed from January 21, 2020, to April 22, 2022.MAIN OUTCOMES AND MEASURES The main study outcome was the group difference in cerebral 5-HT4 receptor binding between patients with MDD and healthy controls. In addition, the association between 5-HT4 receptor binding and verbal memory performance in the patient group was tested. Other cognitive domains (working memory, reaction time, emotion recognition bias, and negative social emotions) were assessed as secondary outcomes.RESULTS A total of 90 patients with untreated MDD (mean [SD] age, 27.1 [8.2] years; 64 women [71.1%]) and 91 healthy controls (mean [SD] age, 27.1 [8.0] years; 55 women [60.4%]) were included in the analysis. Patients with current MDD had significantly lower cerebral 5-HT4 receptor binding than healthy controls (-7.0%; 95% CI, -11.2 to -2.7; P = .002). In patients with MDD, there was a correlation between cerebral 5-HT4 receptor binding and verbal memory (r = 0.29; P = .02).CONCLUSIONS AND RELEVANCE Results of this study show that cerebral 5-HT(4 )receptor binding was lower in patients with MDD than in healthy controls and that the memory dysfunction in patients with MDD was associated with lower cerebral 5-HT4 receptor binding. The cerebral 5-HT4 receptor is a promising treatment target for memory dysfunction in patients with MDD.",
keywords = "POSITRON-EMISSION-TOMOGRAPHY, 5-HT4 RECEPTOR, TREATMENT RESPONSE, AGONIST, ANTIDEPRESSANTS, METAANALYSIS, 1ST-EPISODE, TRANSPORTER, VALIDATION, ACTIVATION",
author = "Kristin Koehler-Forsberg and Dam, {Vibeke H.} and Brice Ozenne and Anjali Sankar and Vincent Beliveau and Landman, {Elizabeth B.} and Larsen, {S{\o}ren V.} and Poulsen, {Asbj{\o}rn S.} and Cheng-Teng Ip and Anders J{\o}rgensen and Michal Meyer and Stenbaek, {Dea S.} and Eiberg, {Hans R. L.} and Jacob Madsen and Claus Svarer and Jorgensen, {Martin B.} and Frokjaer, {Vibe G.} and Knudsen, {Gitte M.}",
year = "2023",
doi = "10.1001/jamapsychiatry.2022.4539",
language = "English",
volume = "80",
pages = "296--304",
journal = "JAMA Psychiatry",
issn = "2168-622X",
publisher = "The JAMA Network",
number = "4",

}

RIS

TY - JOUR

T1 - Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction

AU - Koehler-Forsberg, Kristin

AU - Dam, Vibeke H.

AU - Ozenne, Brice

AU - Sankar, Anjali

AU - Beliveau, Vincent

AU - Landman, Elizabeth B.

AU - Larsen, Søren V.

AU - Poulsen, Asbjørn S.

AU - Ip, Cheng-Teng

AU - Jørgensen, Anders

AU - Meyer, Michal

AU - Stenbaek, Dea S.

AU - Eiberg, Hans R. L.

AU - Madsen, Jacob

AU - Svarer, Claus

AU - Jorgensen, Martin B.

AU - Frokjaer, Vibe G.

AU - Knudsen, Gitte M.

PY - 2023

Y1 - 2023

N2 - IMPORTANCE The cerebral serotonin 4 (5-HT4) receptor is a promising novel target for treatment of major depressive disorder (MDD), and pharmacological stimulation of the 5-HT4 receptor has been associated with improved learning and memory in healthy individuals.OBJECTIVE To map the neurobiological signatures of patients with untreated MDD compared with healthy controls and to examine the association between cerebral 5-HT4 receptor binding and cognitive functions in the depressed state.DESIGN, SETTING, AND PARTICIPANTS This case-control study used baseline data from the NeuroPharm clinical depression trial in Denmark. Adult participants included antidepressant-free outpatients with a current moderate to severe depressive episode and healthy controls. All participants completed positron emission tomography (PET) scanning with [C-11]SB207145 for quantification of brain 5-HT4 receptor binding, but only the patients underwent cognitive testing. Data analyses were performed from January 21, 2020, to April 22, 2022.MAIN OUTCOMES AND MEASURES The main study outcome was the group difference in cerebral 5-HT4 receptor binding between patients with MDD and healthy controls. In addition, the association between 5-HT4 receptor binding and verbal memory performance in the patient group was tested. Other cognitive domains (working memory, reaction time, emotion recognition bias, and negative social emotions) were assessed as secondary outcomes.RESULTS A total of 90 patients with untreated MDD (mean [SD] age, 27.1 [8.2] years; 64 women [71.1%]) and 91 healthy controls (mean [SD] age, 27.1 [8.0] years; 55 women [60.4%]) were included in the analysis. Patients with current MDD had significantly lower cerebral 5-HT4 receptor binding than healthy controls (-7.0%; 95% CI, -11.2 to -2.7; P = .002). In patients with MDD, there was a correlation between cerebral 5-HT4 receptor binding and verbal memory (r = 0.29; P = .02).CONCLUSIONS AND RELEVANCE Results of this study show that cerebral 5-HT(4 )receptor binding was lower in patients with MDD than in healthy controls and that the memory dysfunction in patients with MDD was associated with lower cerebral 5-HT4 receptor binding. The cerebral 5-HT4 receptor is a promising treatment target for memory dysfunction in patients with MDD.

AB - IMPORTANCE The cerebral serotonin 4 (5-HT4) receptor is a promising novel target for treatment of major depressive disorder (MDD), and pharmacological stimulation of the 5-HT4 receptor has been associated with improved learning and memory in healthy individuals.OBJECTIVE To map the neurobiological signatures of patients with untreated MDD compared with healthy controls and to examine the association between cerebral 5-HT4 receptor binding and cognitive functions in the depressed state.DESIGN, SETTING, AND PARTICIPANTS This case-control study used baseline data from the NeuroPharm clinical depression trial in Denmark. Adult participants included antidepressant-free outpatients with a current moderate to severe depressive episode and healthy controls. All participants completed positron emission tomography (PET) scanning with [C-11]SB207145 for quantification of brain 5-HT4 receptor binding, but only the patients underwent cognitive testing. Data analyses were performed from January 21, 2020, to April 22, 2022.MAIN OUTCOMES AND MEASURES The main study outcome was the group difference in cerebral 5-HT4 receptor binding between patients with MDD and healthy controls. In addition, the association between 5-HT4 receptor binding and verbal memory performance in the patient group was tested. Other cognitive domains (working memory, reaction time, emotion recognition bias, and negative social emotions) were assessed as secondary outcomes.RESULTS A total of 90 patients with untreated MDD (mean [SD] age, 27.1 [8.2] years; 64 women [71.1%]) and 91 healthy controls (mean [SD] age, 27.1 [8.0] years; 55 women [60.4%]) were included in the analysis. Patients with current MDD had significantly lower cerebral 5-HT4 receptor binding than healthy controls (-7.0%; 95% CI, -11.2 to -2.7; P = .002). In patients with MDD, there was a correlation between cerebral 5-HT4 receptor binding and verbal memory (r = 0.29; P = .02).CONCLUSIONS AND RELEVANCE Results of this study show that cerebral 5-HT(4 )receptor binding was lower in patients with MDD than in healthy controls and that the memory dysfunction in patients with MDD was associated with lower cerebral 5-HT4 receptor binding. The cerebral 5-HT4 receptor is a promising treatment target for memory dysfunction in patients with MDD.

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - 5-HT4 RECEPTOR

KW - TREATMENT RESPONSE

KW - AGONIST

KW - ANTIDEPRESSANTS

KW - METAANALYSIS

KW - 1ST-EPISODE

KW - TRANSPORTER

KW - VALIDATION

KW - ACTIVATION

U2 - 10.1001/jamapsychiatry.2022.4539

DO - 10.1001/jamapsychiatry.2022.4539

M3 - Journal article

C2 - 36753296

VL - 80

SP - 296

EP - 304

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

IS - 4

ER -

ID: 339580039