TY - JOUR

T1 - Hot and Cold Cognitive Disturbances in Parkinson Patients Treated with DBS‐STN

T2 - A Combined PET and Neuropsychological Study

AU - Jørgensen, Louise M.

AU - Henriksen, Tove

AU - Mardosiene, Skirmante

AU - Wyon, Ottilia

AU - Keller, Sune H.

AU - Jespersen, Bo

AU - Knudsen, Gitte M.

AU - Stenbæk, Dea S.

N1 - Funding Information: Funding: This research was funded by the Lundbeck Foundation grant (R170 2014 994 and R183 2014 3836) and the Independent Research Fund Denmark (9039‐00314B) covered the salary for L.M.J. and the running costs. Additional funding came from the Aase and Ejnar Danielsens Fond (10‐ 001296) and Fonden til Lægevidenskabens Fremme (13‐216). Funding Information: This research was funded by the Lundbeck Foundation grant (R170 2014 994 and R183 2014 3836) and the Independent Research Fund Denmark (9039‐00314B) covered the salary for L.M.J. and the running costs. Additional funding came from the Aase and Ejnar Danielsens Fond (10‐ 001296) and Fonden til Lægevidenskabens Fremme (13‐216). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/5

Y1 - 2022/5

N2 - Patients with Parkinson’s disease (PD) often suffer from non‐motor symptoms, which may be caused by serotonergic dysfunction. Deep Brain Stimulation (DBS) in the subthalamic nucleus (STN) may also influence non‐motor symptoms. The aim of this study is to investigate how the cerebral 5‐HT system associates to disturbances in cognition and mood in PD patients with DBS‐ STN turned on and off. We used psychological tests and questionnaires to evaluate cognitive function and the effects on mood from turning DBS‐STN off. We applied a novel PET neuroimaging methodology to evaluate the integrity of the cerebral serotonin system. We measured 5‐HT1BR binding in 13 DBS‐STN‐treated PD patients, at baseline and after turning DBS off. Thirteen age-matched volunteers served as controls. The measures for cognition and mood were correlated to the 5‐HT1BR availability in temporal limbic cortex. 5‐HT1BR binding was proportional to working memory performance and inverse proportional to affective bias for face recognition. When DBS is turned off, patients feel less vigorous; the higher the limbic and temporal 5‐HT1BR binding, the more they are affected by DBS being turned off. Our study suggests that cerebral 5‐HTR binding is associated with non‐motor symptoms, and that preservation of serotonergic functions may be predictive of DBS‐STN effects.

AB - Patients with Parkinson’s disease (PD) often suffer from non‐motor symptoms, which may be caused by serotonergic dysfunction. Deep Brain Stimulation (DBS) in the subthalamic nucleus (STN) may also influence non‐motor symptoms. The aim of this study is to investigate how the cerebral 5‐HT system associates to disturbances in cognition and mood in PD patients with DBS‐ STN turned on and off. We used psychological tests and questionnaires to evaluate cognitive function and the effects on mood from turning DBS‐STN off. We applied a novel PET neuroimaging methodology to evaluate the integrity of the cerebral serotonin system. We measured 5‐HT1BR binding in 13 DBS‐STN‐treated PD patients, at baseline and after turning DBS off. Thirteen age-matched volunteers served as controls. The measures for cognition and mood were correlated to the 5‐HT1BR availability in temporal limbic cortex. 5‐HT1BR binding was proportional to working memory performance and inverse proportional to affective bias for face recognition. When DBS is turned off, patients feel less vigorous; the higher the limbic and temporal 5‐HT1BR binding, the more they are affected by DBS being turned off. Our study suggests that cerebral 5‐HTR binding is associated with non‐motor symptoms, and that preservation of serotonergic functions may be predictive of DBS‐STN effects.

KW - cognition

KW - deep brain stimulation

KW - mood

KW - neuroimaging

KW - non‐motor symptoms

KW - Parkinson

KW - positron emission tomography

KW - serotonin (5‐HT)

KW - subthalamic nucleus

U2 - 10.3390/brainsci12050654

DO - 10.3390/brainsci12050654

M3 - Journal article

C2 - 35625040

AN - SCOPUS:85130715574

VL - 12

JO - Brain Sciences

JF - Brain Sciences

SN - 2076-3425

IS - 5

M1 - 654

ER -