Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
Acute Tryptophan Depletion (ATD) is a dietary method used to modulate central 5-HT to study the effects of temporarily reduced 5-HT synthesis. The aim of this study is to evaluate a novel method of ATD using a gelatin-based collagen peptide (CP) mixture. We administered CP-Trp or CP+Trp mixtures to 29 healthy volunteers; 13 from a randomized, double-blinded crossover study and sixteen from a randomized, double-blinded study run in our laboratory. Plasma amino acids, mood, side effects, cortisol concentrations, mean arterial blood pressure and heart rate were measured at multiple time-points. Repeated measures analysis of variance and Wilcoxon or Mann-Whitney U non-parametric tests were used to analyze the effects of intervention. Intake of the CP-Trp mixture efficiently reduced plasma Trp; however, the CP+Trp mixture induced a large significant increase in plasma Trp. No other significant effects of CP-Trp compared to CP+Trp were observed. The transient increase in plasma Trp after CP+Trp may impair comparison to the CP-Trp and we therefore recommend in future studies to use a smaller dose of Trp supplement to the CP mixture.
Originalsprog | Engelsk |
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Tidsskrift | European Neuropsychopharmacology |
Vol/bind | 26 |
Udgave nummer | 1 |
Sider (fra-til) | 147-9 |
Antal sider | 3 |
ISSN | 0924-977X |
DOI | |
Status | Udgivet - jan. 2016 |
ID: 164513305