Premorbid functioning in adolescence associates with comorbid disorders in individuals at ultra‐high risk for psychosis: A brief report
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Premorbid functioning in adolescence associates with comorbid disorders in individuals at ultra‐high risk for psychosis : A brief report. / Lundsgaard, Julie; Kristensen, Tina Dam; Nordentoft, Merete; Glenthøj, Louise Birkedal.
I: Early Intervention in Psychiatry, Bind 17, Nr. 4, 2023, s. 422–426.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Premorbid functioning in adolescence associates with comorbid disorders in individuals at ultra‐high risk for psychosis
T2 - A brief report
AU - Lundsgaard, Julie
AU - Kristensen, Tina Dam
AU - Nordentoft, Merete
AU - Glenthøj, Louise Birkedal
PY - 2023
Y1 - 2023
N2 - AimThis study examines associations between premorbid adjustment and comorbid disorders in individuals at ultra-high risk (UHR) for psychosis.MethodsPremorbid social and academic adjustment data were collected from 146 UHR individuals using the Premorbid Adjustment Scale. Comorbid disorders were determined by the Structural Clinical Interview for DSM-IV.ResultsLogistic regressions showed lower premorbid social adjustment associated with personality disorders. Lower premorbid academic adjustment associated with affective disorders. More specifically, poor premorbid social adjustment in early and late adolescence associated with personality disorders. Lower premorbid social adjustment in late adolescence and lower premorbid academic adjustment in early adolescence associated with affective disorders.ConclusionPartly corroborating evidence from schizophrenia samples, our findings suggest that poor premorbid adjustment relate to distinct comorbid disorders in UHR individuals. If replicated, it indicates that premorbid adjustment deficits may be a key area for targeted interventions improving the clinical prognosis of UHR individuals.
AB - AimThis study examines associations between premorbid adjustment and comorbid disorders in individuals at ultra-high risk (UHR) for psychosis.MethodsPremorbid social and academic adjustment data were collected from 146 UHR individuals using the Premorbid Adjustment Scale. Comorbid disorders were determined by the Structural Clinical Interview for DSM-IV.ResultsLogistic regressions showed lower premorbid social adjustment associated with personality disorders. Lower premorbid academic adjustment associated with affective disorders. More specifically, poor premorbid social adjustment in early and late adolescence associated with personality disorders. Lower premorbid social adjustment in late adolescence and lower premorbid academic adjustment in early adolescence associated with affective disorders.ConclusionPartly corroborating evidence from schizophrenia samples, our findings suggest that poor premorbid adjustment relate to distinct comorbid disorders in UHR individuals. If replicated, it indicates that premorbid adjustment deficits may be a key area for targeted interventions improving the clinical prognosis of UHR individuals.
U2 - 10.1111/eip.13373
DO - 10.1111/eip.13373
M3 - Journal article
C2 - 36693622
VL - 17
SP - 422
EP - 426
JO - Early Intervention in Psychiatry
JF - Early Intervention in Psychiatry
SN - 1751-7885
IS - 4
ER -
ID: 333693332