TY - JOUR

T1 - Internet-based cognitive assessment tool

T2 - Sensitivity and validity of a new online cognition screening tool for patients with bipolar disorder

AU - Miskowiak, K. W.

AU - Jespersen, A. E.

AU - Obenhausen, K.

AU - Hafiz, P.

AU - Hestbæk, E.

AU - Gulyas, L.

AU - Kessing, L. V.

AU - Bardram, J. E.

N1 - Funding Information: The Lundbeck Foundation and Weimann Foundation are acknowledged for their contributions to KWM's salary to do full time research. PH is an early stage researcher of technology enabled mental health (TEAM) for young people. TEAM has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 722561. The authors declare having received funding from the Ivan Nielsens Fond, Copenhagen Denmark and the Copenhagen Center for Health Technology (CACHET). This study was supported by a grant from the Ivan Nielsen Foundation. Kamilla Miskowiak: Conceptualization, design of study and ICAT, resources, supervision, writing ? original draft, review and editing. Andreas Jespersen: recruiting, testing, statistical analysis, writing ? original draft. Kia Obenhausen and Emilie Jacobsen: recruiting, writing ? review and editing. Pegah Hafiz and Lorant Gulyas: design and programming of ICAT, piloting, writing - review and editing. Lars Kessing: conceptualization, supervision, writing ? review and editing. Jakob Bardram: conceptualization, design of ICAT, resources, supervision, writing ? review and editing. All authors have read and approved the final version of the manuscript. Funding Information: The Lundbeck Foundation and Weimann Foundation are acknowledged for their contributions to KWM’s salary to do full time research. PH is an early stage researcher of technology enabled mental health (TEAM) for young people. TEAM has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 722561. The authors declare having received funding from the Ivan Nielsens Fond, Copenhagen Denmark and the Copenhagen Center for Health Technology (CACHET). Funding Information: This study was supported by a grant from the Ivan Nielsen Foundation. Publisher Copyright: © 2021

PY - 2021

Y1 - 2021

N2 - Background: The International Society for Bipolar Disorders Targeting Cognition Task Force recommends the Screen for Cognitive Impairment in Psychiatry (SCIP) to screen for cognitive impairment in bipolar disorder. However, SCIP must be administered by a healthcare professional, which is often impossible due to time and resource constraints. Web-based, self-administered cognition screening tools may enable assessment and monitoring of patients’ cognition at a much larger scale to a reduced cost. For this purpose, we developed the Internet-Based Cognitive Assessment Tool (ICAT) as a modified web-based version of SCIP. This study aimed to investigate the sensitivity and validity of ICAT for cognition assessment in bipolar disorder. Method: Thirty-five patients with bipolar disorder in full or partial remission and 35 healthy controls completed ICAT on a computer, the standard paper-and-pencil SCIP and a subjective cognition questionnaire and were rated for mood symptoms and functioning at the Copenhagen Affective Disorders Research Centre. Results: Patients displayed cognitive impairments compared to controls on the ICAT (t (61)=3.67, p<.001, d=0.93). There was a strong correlation between ICAT and SCIP Total Scores (r(61)=.72, p<.000) and moderate to strong correlations on subtest scores (r=.48-.63, ps<.001). Across all participants, lower ICAT scores correlated with more subjective cognitive complaints (r(59)=-.43, p<.001) and poorer psychosocial functioning (r(62)=-.47, p<.001). Conclusion: ICAT is a sensitive and valid web-based tool for cognition assessment in patients with bipolar disorder. This highlights ICAT as a novel web-based cognition screening tool that is feasible for largescale assessment and monitoring of cognition in the clinical management of bipolar disorder.

AB - Background: The International Society for Bipolar Disorders Targeting Cognition Task Force recommends the Screen for Cognitive Impairment in Psychiatry (SCIP) to screen for cognitive impairment in bipolar disorder. However, SCIP must be administered by a healthcare professional, which is often impossible due to time and resource constraints. Web-based, self-administered cognition screening tools may enable assessment and monitoring of patients’ cognition at a much larger scale to a reduced cost. For this purpose, we developed the Internet-Based Cognitive Assessment Tool (ICAT) as a modified web-based version of SCIP. This study aimed to investigate the sensitivity and validity of ICAT for cognition assessment in bipolar disorder. Method: Thirty-five patients with bipolar disorder in full or partial remission and 35 healthy controls completed ICAT on a computer, the standard paper-and-pencil SCIP and a subjective cognition questionnaire and were rated for mood symptoms and functioning at the Copenhagen Affective Disorders Research Centre. Results: Patients displayed cognitive impairments compared to controls on the ICAT (t (61)=3.67, p<.001, d=0.93). There was a strong correlation between ICAT and SCIP Total Scores (r(61)=.72, p<.000) and moderate to strong correlations on subtest scores (r=.48-.63, ps<.001). Across all participants, lower ICAT scores correlated with more subjective cognitive complaints (r(59)=-.43, p<.001) and poorer psychosocial functioning (r(62)=-.47, p<.001). Conclusion: ICAT is a sensitive and valid web-based tool for cognition assessment in patients with bipolar disorder. This highlights ICAT as a novel web-based cognition screening tool that is feasible for largescale assessment and monitoring of cognition in the clinical management of bipolar disorder.

KW - bipolar disorder

KW - Cognitive impairment

KW - online

KW - screening

KW - validation

KW - web-based

U2 - 10.1016/j.jad.2021.04.039

DO - 10.1016/j.jad.2021.04.039

M3 - Journal article

C2 - 33979722

AN - SCOPUS:85105457692

VL - 289

SP - 125

EP - 134

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -