Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention

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Standard

Dissociable Catecholaminergic Modulation of Visual Attention : Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention. / Shalev, Nir; Vangkilde, Signe; Neville, Matt J.; Tunbridge, Elizabeth M.; Nobre, Anna C.; Chechlacz, Magdalena.

I: Neuroscience, Bind 412, 01.08.2019, s. 175-189.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Shalev, N, Vangkilde, S, Neville, MJ, Tunbridge, EM, Nobre, AC & Chechlacz, M 2019, 'Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention', Neuroscience, bind 412, s. 175-189. https://doi.org/10.1016/j.neuroscience.2019.05.068

APA

Shalev, N., Vangkilde, S., Neville, M. J., Tunbridge, E. M., Nobre, A. C., & Chechlacz, M. (2019). Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention. Neuroscience, 412, 175-189. https://doi.org/10.1016/j.neuroscience.2019.05.068

Vancouver

Shalev N, Vangkilde S, Neville MJ, Tunbridge EM, Nobre AC, Chechlacz M. Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention. Neuroscience. 2019 aug 1;412:175-189. https://doi.org/10.1016/j.neuroscience.2019.05.068

Author

Shalev, Nir ; Vangkilde, Signe ; Neville, Matt J. ; Tunbridge, Elizabeth M. ; Nobre, Anna C. ; Chechlacz, Magdalena. / Dissociable Catecholaminergic Modulation of Visual Attention : Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention. I: Neuroscience. 2019 ; Bind 412. s. 175-189.

Bibtex

@article{be749c0651b44f6fb14bde6329a16631,
title = "Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention",
abstract = "Visual attention enables us to prioritise behaviourally relevant visual information while ignoring distraction. The neural networks supporting attention are modulated by two catecholamines, dopamine and noradrenaline. The current study investigated the effects of single nucleotide polymorphisms in two catecholaminergic genes – COMT (Val158Met) and DBH (444 G/A) – on individual differences in attention functions. Participants (n = 125) were recruited from the Oxford Biobank by genotype-based recall. They were tested on a continuous performance task (sustained attention), a Go/No-Go task (response inhibition), and a task assessing attentional selection in accordance with the Theory of Visual Attention (TVA). We found a significant effect of DBH genotype status on the capacity to maintain attention over time (sustained attention) as measured by the continuous performance task. Furthermore, we demonstrated a significant association between COMT genotype status and effective threshold of visual perception in attentional selection as estimated based on the TVA task performance. No other group differences in attention function were found with respect to the studied genotypes. Overall, our findings provide novel experimental evidence that: (i) dopaminergic and noradrenergic genotypes have dissociable effects on visual attention; (ii) either insufficient or excessive catecholaminergic activity may have equally detrimental effects on sustained attention.",
keywords = "attentional selection, catecholamines, COMT, DBH, individual differences, sustained attention",
author = "Nir Shalev and Signe Vangkilde and Neville, {Matt J.} and Tunbridge, {Elizabeth M.} and Nobre, {Anna C.} and Magdalena Chechlacz",
year = "2019",
month = aug,
day = "1",
doi = "10.1016/j.neuroscience.2019.05.068",
language = "English",
volume = "412",
pages = "175--189",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Dissociable Catecholaminergic Modulation of Visual Attention

T2 - Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention

AU - Shalev, Nir

AU - Vangkilde, Signe

AU - Neville, Matt J.

AU - Tunbridge, Elizabeth M.

AU - Nobre, Anna C.

AU - Chechlacz, Magdalena

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Visual attention enables us to prioritise behaviourally relevant visual information while ignoring distraction. The neural networks supporting attention are modulated by two catecholamines, dopamine and noradrenaline. The current study investigated the effects of single nucleotide polymorphisms in two catecholaminergic genes – COMT (Val158Met) and DBH (444 G/A) – on individual differences in attention functions. Participants (n = 125) were recruited from the Oxford Biobank by genotype-based recall. They were tested on a continuous performance task (sustained attention), a Go/No-Go task (response inhibition), and a task assessing attentional selection in accordance with the Theory of Visual Attention (TVA). We found a significant effect of DBH genotype status on the capacity to maintain attention over time (sustained attention) as measured by the continuous performance task. Furthermore, we demonstrated a significant association between COMT genotype status and effective threshold of visual perception in attentional selection as estimated based on the TVA task performance. No other group differences in attention function were found with respect to the studied genotypes. Overall, our findings provide novel experimental evidence that: (i) dopaminergic and noradrenergic genotypes have dissociable effects on visual attention; (ii) either insufficient or excessive catecholaminergic activity may have equally detrimental effects on sustained attention.

AB - Visual attention enables us to prioritise behaviourally relevant visual information while ignoring distraction. The neural networks supporting attention are modulated by two catecholamines, dopamine and noradrenaline. The current study investigated the effects of single nucleotide polymorphisms in two catecholaminergic genes – COMT (Val158Met) and DBH (444 G/A) – on individual differences in attention functions. Participants (n = 125) were recruited from the Oxford Biobank by genotype-based recall. They were tested on a continuous performance task (sustained attention), a Go/No-Go task (response inhibition), and a task assessing attentional selection in accordance with the Theory of Visual Attention (TVA). We found a significant effect of DBH genotype status on the capacity to maintain attention over time (sustained attention) as measured by the continuous performance task. Furthermore, we demonstrated a significant association between COMT genotype status and effective threshold of visual perception in attentional selection as estimated based on the TVA task performance. No other group differences in attention function were found with respect to the studied genotypes. Overall, our findings provide novel experimental evidence that: (i) dopaminergic and noradrenergic genotypes have dissociable effects on visual attention; (ii) either insufficient or excessive catecholaminergic activity may have equally detrimental effects on sustained attention.

KW - attentional selection

KW - catecholamines

KW - COMT

KW - DBH

KW - individual differences

KW - sustained attention

U2 - 10.1016/j.neuroscience.2019.05.068

DO - 10.1016/j.neuroscience.2019.05.068

M3 - Journal article

C2 - 31195057

AN - SCOPUS:85067877006

VL - 412

SP - 175

EP - 189

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -

ID: 236722113