Based on lexical studies, the HEXACO (honesty-humility, emotionality, extraversion, agreeableness, conscientiousness, and openness to experience) model of personality has been proposed as a model of basic personality structure that summarizes individual differences in six broad trait dimensions. Although research across various fields relies on the HEXACO model increasingly, a comprehensive investigation of the nomological net of the HEXACO dimensions is missing entirely. Thus, it remains unclear whether each HEXACO dimension accounts for individual variation across theoretically relevant outcome criteria. We close this gap through a large-scale meta-analytic investigation, testing whether each HEXACO dimension is uniquely linked to one broad and theoretically relevant outcome domain. Results from 426 individual meta-analyses, 436 independent samples, and 3,893 effect-size estimates corroborate this unique mapping. Specifically, honesty-humility maps onto the outcome domain of exploitation, emotionality onto insecurity, extraversion onto sociality, agreeableness versus anger onto obstruction, conscientiousness onto duty, and openness to experience onto exploration. Overall, the current investigation provides a comprehensive empirical test of the (breadth of) content captured by the HEXACO dimensions and allows for a broad specification of the nomological net of the HEXACO model overall.