Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity—Comparison with other anxiety-related temperamental dimensions

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Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity—Comparison with other anxiety-related temperamental dimensions. / Licht, Cecilie L.; Mortensen, Erik L.; Hjordt, Liv V.; Stenbæk, Dea S.; Arentzen, Tine E.; Nørremølle, Anne; Knudsen, Gitte M.

I: Molecular Genetics and Genomic Medicine, Bind 8, Nr. 8, e1352, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Licht, CL, Mortensen, EL, Hjordt, LV, Stenbæk, DS, Arentzen, TE, Nørremølle, A & Knudsen, GM 2020, 'Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity—Comparison with other anxiety-related temperamental dimensions', Molecular Genetics and Genomic Medicine, bind 8, nr. 8, e1352. https://doi.org/10.1002/mgg3.1352

APA

Licht, C. L., Mortensen, E. L., Hjordt, L. V., Stenbæk, D. S., Arentzen, T. E., Nørremølle, A., & Knudsen, G. M. (2020). Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity—Comparison with other anxiety-related temperamental dimensions. Molecular Genetics and Genomic Medicine, 8(8), [e1352]. https://doi.org/10.1002/mgg3.1352

Vancouver

Licht CL, Mortensen EL, Hjordt LV, Stenbæk DS, Arentzen TE, Nørremølle A o.a. Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity—Comparison with other anxiety-related temperamental dimensions. Molecular Genetics and Genomic Medicine. 2020;8(8). e1352. https://doi.org/10.1002/mgg3.1352

Author

Licht, Cecilie L. ; Mortensen, Erik L. ; Hjordt, Liv V. ; Stenbæk, Dea S. ; Arentzen, Tine E. ; Nørremølle, Anne ; Knudsen, Gitte M. / Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity—Comparison with other anxiety-related temperamental dimensions. I: Molecular Genetics and Genomic Medicine. 2020 ; Bind 8, Nr. 8.

Bibtex

@article{c03a2bdf536d49f5b9a1145df1d5c376,
title = "Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity—Comparison with other anxiety-related temperamental dimensions",
abstract = "Background: The short (s) allele of the 5-HTTLPR polymorphism in the promoter region of the human serotonin transporter (5-HTT) gene SLC6A4 has previously been associated with anxiety-related personality dimensions. However, this relationship has not been confirmed in all studies and may be modified by environmental circumstances and/or psychiatric illness. This study examined whether the temperamental trait sensory processing sensitivity (SPS), characterized by increased responsivity to environmental stimuli, is related to 5-HTTLPR/rs25531 genotype. Methods: 5-HTTLPR and rs25531 genotypes, level of SPS, self-reported Revised NEO Personality Inventory (NEO-PI-R) and Temperament and Character Inventory (TCI) personality profiles, and symptoms of psychological distress (SCL-90R Global Severity Index) were determined for 405 healthy volunteers. Results: Sensory processing sensitivity was highly correlated with the anxiety-related dimensions of the NEO-PI-R and the TCI models of personality, Neuroticism, and Harm Avoidance, respectively. However, the level of SPS was not associated with the combined 5-HTTLPR and rs25531 s′/s′ genotype. Neuroticism and Harm Avoidance were also not associated with 5-HTTLPR/rs25531 s′/s′ genotype. Correcting for symptoms of psychological distress had no effect on the relationships between personality and genotype. Conclusion: The level of SPS was not associated with serotonin transporter gene variation. Further, combined 5-HTTLPR and rs25531 genotype was not associated with other anxiety-related dimensions.",
keywords = "Harm Avoidance, Neuroticism, personality, serotonin, temperament",
author = "Licht, {Cecilie L.} and Mortensen, {Erik L.} and Hjordt, {Liv V.} and Stenb{\ae}k, {Dea S.} and Arentzen, {Tine E.} and Anne N{\o}rrem{\o}lle and Knudsen, {Gitte M.}",
year = "2020",
doi = "10.1002/mgg3.1352",
language = "English",
volume = "8",
journal = "Molecular genetics & genomic medicine",
issn = "2324-9269",
publisher = "JohnWiley & Sons Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity—Comparison with other anxiety-related temperamental dimensions

AU - Licht, Cecilie L.

AU - Mortensen, Erik L.

AU - Hjordt, Liv V.

AU - Stenbæk, Dea S.

AU - Arentzen, Tine E.

AU - Nørremølle, Anne

AU - Knudsen, Gitte M.

PY - 2020

Y1 - 2020

N2 - Background: The short (s) allele of the 5-HTTLPR polymorphism in the promoter region of the human serotonin transporter (5-HTT) gene SLC6A4 has previously been associated with anxiety-related personality dimensions. However, this relationship has not been confirmed in all studies and may be modified by environmental circumstances and/or psychiatric illness. This study examined whether the temperamental trait sensory processing sensitivity (SPS), characterized by increased responsivity to environmental stimuli, is related to 5-HTTLPR/rs25531 genotype. Methods: 5-HTTLPR and rs25531 genotypes, level of SPS, self-reported Revised NEO Personality Inventory (NEO-PI-R) and Temperament and Character Inventory (TCI) personality profiles, and symptoms of psychological distress (SCL-90R Global Severity Index) were determined for 405 healthy volunteers. Results: Sensory processing sensitivity was highly correlated with the anxiety-related dimensions of the NEO-PI-R and the TCI models of personality, Neuroticism, and Harm Avoidance, respectively. However, the level of SPS was not associated with the combined 5-HTTLPR and rs25531 s′/s′ genotype. Neuroticism and Harm Avoidance were also not associated with 5-HTTLPR/rs25531 s′/s′ genotype. Correcting for symptoms of psychological distress had no effect on the relationships between personality and genotype. Conclusion: The level of SPS was not associated with serotonin transporter gene variation. Further, combined 5-HTTLPR and rs25531 genotype was not associated with other anxiety-related dimensions.

AB - Background: The short (s) allele of the 5-HTTLPR polymorphism in the promoter region of the human serotonin transporter (5-HTT) gene SLC6A4 has previously been associated with anxiety-related personality dimensions. However, this relationship has not been confirmed in all studies and may be modified by environmental circumstances and/or psychiatric illness. This study examined whether the temperamental trait sensory processing sensitivity (SPS), characterized by increased responsivity to environmental stimuli, is related to 5-HTTLPR/rs25531 genotype. Methods: 5-HTTLPR and rs25531 genotypes, level of SPS, self-reported Revised NEO Personality Inventory (NEO-PI-R) and Temperament and Character Inventory (TCI) personality profiles, and symptoms of psychological distress (SCL-90R Global Severity Index) were determined for 405 healthy volunteers. Results: Sensory processing sensitivity was highly correlated with the anxiety-related dimensions of the NEO-PI-R and the TCI models of personality, Neuroticism, and Harm Avoidance, respectively. However, the level of SPS was not associated with the combined 5-HTTLPR and rs25531 s′/s′ genotype. Neuroticism and Harm Avoidance were also not associated with 5-HTTLPR/rs25531 s′/s′ genotype. Correcting for symptoms of psychological distress had no effect on the relationships between personality and genotype. Conclusion: The level of SPS was not associated with serotonin transporter gene variation. Further, combined 5-HTTLPR and rs25531 genotype was not associated with other anxiety-related dimensions.

KW - Harm Avoidance

KW - Neuroticism

KW - personality

KW - serotonin

KW - temperament

U2 - 10.1002/mgg3.1352

DO - 10.1002/mgg3.1352

M3 - Journal article

C2 - 32543106

AN - SCOPUS:85086433690

VL - 8

JO - Molecular genetics & genomic medicine

JF - Molecular genetics & genomic medicine

SN - 2324-9269

IS - 8

M1 - e1352

ER -

ID: 243338346