Rumination-focused cognitive behaviour therapy vs. cognitive behaviour therapy for depression: Study protocol for a randomised controlled superiority trial

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Rumination-focused cognitive behaviour therapy vs. cognitive behaviour therapy for depression : Study protocol for a randomised controlled superiority trial. / Hvenegaard, Morten ; Watkins, Ed R; Poulsen, Stig; Rosenberg, Nicole K; Gondan, Matthias; Grafton, Ben; Austin, Stephen F; Howard, Henriette; Moeller, Stine B.

I: Trials, Bind 16, Nr. 1, 344, 2015, s. 1-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Hvenegaard, M, Watkins, ER, Poulsen, S, Rosenberg, NK, Gondan, M, Grafton, B, Austin, SF, Howard, H & Moeller, SB 2015, 'Rumination-focused cognitive behaviour therapy vs. cognitive behaviour therapy for depression: Study protocol for a randomised controlled superiority trial', Trials, bind 16, nr. 1, 344, s. 1-6. https://doi.org/10.1186/s13063-015-0875-y

APA

Hvenegaard, M., Watkins, E. R., Poulsen, S., Rosenberg, N. K., Gondan, M., Grafton, B., Austin, S. F., Howard, H., & Moeller, S. B. (2015). Rumination-focused cognitive behaviour therapy vs. cognitive behaviour therapy for depression: Study protocol for a randomised controlled superiority trial. Trials, 16(1), 1-6. [344]. https://doi.org/10.1186/s13063-015-0875-y

Vancouver

Hvenegaard M, Watkins ER, Poulsen S, Rosenberg NK, Gondan M, Grafton B o.a. Rumination-focused cognitive behaviour therapy vs. cognitive behaviour therapy for depression: Study protocol for a randomised controlled superiority trial. Trials. 2015;16(1):1-6. 344. https://doi.org/10.1186/s13063-015-0875-y

Author

Hvenegaard, Morten ; Watkins, Ed R ; Poulsen, Stig ; Rosenberg, Nicole K ; Gondan, Matthias ; Grafton, Ben ; Austin, Stephen F ; Howard, Henriette ; Moeller, Stine B. / Rumination-focused cognitive behaviour therapy vs. cognitive behaviour therapy for depression : Study protocol for a randomised controlled superiority trial. I: Trials. 2015 ; Bind 16, Nr. 1. s. 1-6.

Bibtex

@article{ef57590052b449e1a125593a2561a974,
title = "Rumination-focused cognitive behaviour therapy vs. cognitive behaviour therapy for depression: Study protocol for a randomised controlled superiority trial",
abstract = "BACKGROUND: Cognitive behavioural therapy is an effective treatment for depression. However, one third of the patients do not respond satisfactorily, and relapse rates of around 30 % within the first post-treatment year were reported in a recent meta-analysis. In total, 30-50 % of remitted patients present with residual symptoms by the end of treatment. A common residual symptom is rumination, a process of recurrent negative thinking and dwelling on negative affect. Rumination has been demonstrated as a major factor in vulnerability to depression, predicting the onset, severity, and duration of future depression. Rumination-focused cognitive behavioural therapy is a psychotherapeutic treatment targeting rumination. Because rumination plays a major role in the initiation and maintenance of depression, targeting rumination with rumination-focused cognitive behavioural therapy may be more effective in treating depression and reducing relapse than standard cognitive behavioural therapy.METHOD/DESIGN: This study is a two-arm pragmatic randomised controlled superiority trial comparing the effectiveness of group-based rumination-focused cognitive behaviour therapy with the effectiveness of group-based cognitive behavioural therapy for treatment of depression. One hundred twenty-eight patients with depression will be recruited from and given treatment in an outpatient service at a psychiatric hospital in Denmark. Our primary outcome will be severity of depressive symptoms (Hamilton Rating Scale for Depression) at completion of treatment. Secondary outcomes will be level of rumination, worry, anxiety, quality of life, behavioural activation, experimental measures of cognitive flexibility, and emotional attentional bias. A 6-month follow-up is planned and will include the primary outcome measure and assessment of relapse.DISCUSSION: The clinical outcome of this trial may guide clinicians to decide on the merits of including rumination-focused cognitive behavioural therapy in the treatment of depression in outpatient services.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02278224 , registered 28 Oct. 2014.",
author = "Morten Hvenegaard and Watkins, {Ed R} and Stig Poulsen and Rosenberg, {Nicole K} and Matthias Gondan and Ben Grafton and Austin, {Stephen F} and Henriette Howard and Moeller, {Stine B}",
year = "2015",
doi = "10.1186/s13063-015-0875-y",
language = "English",
volume = "16",
pages = "1--6",
journal = "Trials",
issn = "1745-6215",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Rumination-focused cognitive behaviour therapy vs. cognitive behaviour therapy for depression

T2 - Study protocol for a randomised controlled superiority trial

AU - Hvenegaard, Morten

AU - Watkins, Ed R

AU - Poulsen, Stig

AU - Rosenberg, Nicole K

AU - Gondan, Matthias

AU - Grafton, Ben

AU - Austin, Stephen F

AU - Howard, Henriette

AU - Moeller, Stine B

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Cognitive behavioural therapy is an effective treatment for depression. However, one third of the patients do not respond satisfactorily, and relapse rates of around 30 % within the first post-treatment year were reported in a recent meta-analysis. In total, 30-50 % of remitted patients present with residual symptoms by the end of treatment. A common residual symptom is rumination, a process of recurrent negative thinking and dwelling on negative affect. Rumination has been demonstrated as a major factor in vulnerability to depression, predicting the onset, severity, and duration of future depression. Rumination-focused cognitive behavioural therapy is a psychotherapeutic treatment targeting rumination. Because rumination plays a major role in the initiation and maintenance of depression, targeting rumination with rumination-focused cognitive behavioural therapy may be more effective in treating depression and reducing relapse than standard cognitive behavioural therapy.METHOD/DESIGN: This study is a two-arm pragmatic randomised controlled superiority trial comparing the effectiveness of group-based rumination-focused cognitive behaviour therapy with the effectiveness of group-based cognitive behavioural therapy for treatment of depression. One hundred twenty-eight patients with depression will be recruited from and given treatment in an outpatient service at a psychiatric hospital in Denmark. Our primary outcome will be severity of depressive symptoms (Hamilton Rating Scale for Depression) at completion of treatment. Secondary outcomes will be level of rumination, worry, anxiety, quality of life, behavioural activation, experimental measures of cognitive flexibility, and emotional attentional bias. A 6-month follow-up is planned and will include the primary outcome measure and assessment of relapse.DISCUSSION: The clinical outcome of this trial may guide clinicians to decide on the merits of including rumination-focused cognitive behavioural therapy in the treatment of depression in outpatient services.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02278224 , registered 28 Oct. 2014.

AB - BACKGROUND: Cognitive behavioural therapy is an effective treatment for depression. However, one third of the patients do not respond satisfactorily, and relapse rates of around 30 % within the first post-treatment year were reported in a recent meta-analysis. In total, 30-50 % of remitted patients present with residual symptoms by the end of treatment. A common residual symptom is rumination, a process of recurrent negative thinking and dwelling on negative affect. Rumination has been demonstrated as a major factor in vulnerability to depression, predicting the onset, severity, and duration of future depression. Rumination-focused cognitive behavioural therapy is a psychotherapeutic treatment targeting rumination. Because rumination plays a major role in the initiation and maintenance of depression, targeting rumination with rumination-focused cognitive behavioural therapy may be more effective in treating depression and reducing relapse than standard cognitive behavioural therapy.METHOD/DESIGN: This study is a two-arm pragmatic randomised controlled superiority trial comparing the effectiveness of group-based rumination-focused cognitive behaviour therapy with the effectiveness of group-based cognitive behavioural therapy for treatment of depression. One hundred twenty-eight patients with depression will be recruited from and given treatment in an outpatient service at a psychiatric hospital in Denmark. Our primary outcome will be severity of depressive symptoms (Hamilton Rating Scale for Depression) at completion of treatment. Secondary outcomes will be level of rumination, worry, anxiety, quality of life, behavioural activation, experimental measures of cognitive flexibility, and emotional attentional bias. A 6-month follow-up is planned and will include the primary outcome measure and assessment of relapse.DISCUSSION: The clinical outcome of this trial may guide clinicians to decide on the merits of including rumination-focused cognitive behavioural therapy in the treatment of depression in outpatient services.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02278224 , registered 28 Oct. 2014.

U2 - 10.1186/s13063-015-0875-y

DO - 10.1186/s13063-015-0875-y

M3 - Journal article

C2 - 26260780

VL - 16

SP - 1

EP - 6

JO - Trials

JF - Trials

SN - 1745-6215

IS - 1

M1 - 344

ER -

ID: 142519391